Osteogenesis imperfecta (OI) is a heritable condition characterized by fragile bones. Our
previous studies indicated that serum 25-hydroxyvitamin D (25OHD) concentrations were
positively associated with lumbar spine areal bone mineral density (LS-aBMD) in children
and adolescents with OI. Here we assessed whether one year of high-dose vitamin D
supplementation results in higher LS-aBMD z-scores in youth with OI. A one-year double-
blind randomized controlled trial conducted at a pediatric orthopedic hospital in Montreal …

Background: Osteogenesis imperfecta (OI) is a genetic disease characterized by fragile
bones and short stature. A recent study showed serum 25-hydroxyvitamin D (25OHD)
concentrations to be positively associated with lumbar spine areal bone mineral density (LS-
aBMD) in patients with OI. Objectives: To assess whether high-dose vitamin D
supplementation will result in significantly higher LS-aBMD z-scores after one-year; and to
evaluate the effect of vitamin D supplementation on lower limb muscle power assessed …