Effect of hypercapnia, an element of obstructive respiratory disorder, on pancreatic cancer chemoresistance and progression
A Nevler, SZ Brown, D Nauheim, C Portocarrero… - Journal of the American …, 2020 - Elsevier
Background Chronic obstructive respiratory disorders (ORDs) are linked to increased rates
of cancer-related deaths. Little is known about the effects of hypercapnia (elevated CO 2) on
development of pancreatic ductal adenocarcinoma (PDAC) and drug resistance. Study
Design Two PDAC cell lines were exposed to normocapnic (5% CO 2) and hypercapnic
(continuous/intermittent 10% CO 2) conditions, physiologically similar to patients with active
ORD. Cells were assessed for proliferation rate, colony formation, and chemo …
of cancer-related deaths. Little is known about the effects of hypercapnia (elevated CO 2) on
development of pancreatic ductal adenocarcinoma (PDAC) and drug resistance. Study
Design Two PDAC cell lines were exposed to normocapnic (5% CO 2) and hypercapnic
(continuous/intermittent 10% CO 2) conditions, physiologically similar to patients with active
ORD. Cells were assessed for proliferation rate, colony formation, and chemo …
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