Effect of insulin glargine up-titration vs insulin degludec/liraglutide on glycated hemoglobin levels in patients with uncontrolled type 2 diabetes: the DUAL V …

I Lingvay, FP Manghi, P García-Hernández, P Norwood… - Jama, 2016 - jamanetwork.com
Importance Achieving glycemic control remains a challenge for patients with type 2 diabetes,
even with insulin therapy. Objective To assess whether a fixed ratio of insulin
degludec/liraglutide was noninferior to continued titration of insulin glargine in patients with
uncontrolled type 2 diabetes treated with insulin glargine and metformin. Design, Setting,
and Participants Phase 3, multinational, multicenter, 26-week, randomized, open-label, 2-
group, treat-to-target trial conducted at 75 centers in 10 countries from September 2013 to …
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