Effect of levofloxacin prophylaxis on bacteremia in children with acute leukemia or undergoing hematopoietic stem cell transplantation: a randomized clinical trial
Importance Bacteremia causes considerable morbidity among children with acute leukemia
and those undergoing hematopoietic stem cell transplantation (HSCT). There are limited
data on the effect of antibiotic prophylaxis in children. Objective To determine the efficacy
and risks of levofloxacin prophylaxis in children receiving intensive chemotherapy for acute
leukemia or undergoing HSCT. Design, Setting, and Participants In this multicenter, open-
label, randomized trial, patients (6 months-21 years) receiving intensive chemotherapy were …
and those undergoing hematopoietic stem cell transplantation (HSCT). There are limited
data on the effect of antibiotic prophylaxis in children. Objective To determine the efficacy
and risks of levofloxacin prophylaxis in children receiving intensive chemotherapy for acute
leukemia or undergoing HSCT. Design, Setting, and Participants In this multicenter, open-
label, randomized trial, patients (6 months-21 years) receiving intensive chemotherapy were …
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