Effect of mannitol and furosemide on plasma osmolality and brain water
K Thenuwara, MM Todd, JE Brian - The Journal of the American …, 2002 - pubs.asahq.org
Background Mannitol and furosemide are used to reduce increased intracranial pressure
(ICP) and to reduce brain bulk during neurosurgery. One mechanism by which these
changes might occur is via a reduction in brain water content. Although mannitol and
furosemide are commonly used in combination, there has been no formal evaluation of the
interactive effects of these two drugs on brain water. The effect of mannitol and furosemide
alone and in combination on water content of normal rat brain was examined. Methods The …
(ICP) and to reduce brain bulk during neurosurgery. One mechanism by which these
changes might occur is via a reduction in brain water content. Although mannitol and
furosemide are commonly used in combination, there has been no formal evaluation of the
interactive effects of these two drugs on brain water. The effect of mannitol and furosemide
alone and in combination on water content of normal rat brain was examined. Methods The …
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