Importance Postpartum depression (PPD) is one of the most common medical complications
during and after pregnancy, negatively affecting both mother and child. Objective To
demonstrate the efficacy and safety of zuranolone, a neuroactive steroid γ-aminobutyric acid
receptor–positive allosteric modulator, in PPD. Design, Setting, and Participants This phase
3, double-blind, randomized, outpatient, placebo-controlled clinical trial was conducted
between January 2017 and December 2018 in 27 enrolling US sites. Participant were …