Effectiveness of non-steroidal anti-inflammatory drugs among patients with primary hypertrophic osteoarthropathy: A systematic review
P Shakya, KN Pokhrel, LB Mlunde, S Tan, E Ota… - Journal of …, 2018 - Elsevier
Background Primary hypertrophic osteoarthropathy (PHO), also known as
pachydermoperiostosis is a rare genetic disease which predominantly affects skin, bone and
soft connective tissue. It is characterized by the triad of pachydermia, digital clubbing and
periostosis of long bones. Arthralgia or arthritis is also present in most of the cases. Genetic
studies have identified the impaired PGE2 metabolism as a culprit for hypertrophic
osteoarthropathy in PHO cases. We conducted a systematic review to examine the …
pachydermoperiostosis is a rare genetic disease which predominantly affects skin, bone and
soft connective tissue. It is characterized by the triad of pachydermia, digital clubbing and
periostosis of long bones. Arthralgia or arthritis is also present in most of the cases. Genetic
studies have identified the impaired PGE2 metabolism as a culprit for hypertrophic
osteoarthropathy in PHO cases. We conducted a systematic review to examine the …
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