Effects of cyclin D1 (CCND1) polymorphism on susceptibility to lung cancer in a North Indian population
Cyclin D1 is involved in normal regulation of the cell cycle and plays an important role in the
transition from G1 to S phase of the cell cycle. The CCND1 gene has a G→ A polymorphism
in exon 4 that increases the frequency of alternate splicing. We analyzed the potential role of
CCND1 gene polymorphisms in lung cancer patients (n= 151) and in a matched control
population (n= 151). DNA was isolated from blood samples, and exon 4 of CCND1 was
amplified by polymerase chain reaction. After digestion with MspI, common CCND1 …
transition from G1 to S phase of the cell cycle. The CCND1 gene has a G→ A polymorphism
in exon 4 that increases the frequency of alternate splicing. We analyzed the potential role of
CCND1 gene polymorphisms in lung cancer patients (n= 151) and in a matched control
population (n= 151). DNA was isolated from blood samples, and exon 4 of CCND1 was
amplified by polymerase chain reaction. After digestion with MspI, common CCND1 …
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