It has been suggested that proteinase enzymes could play an important role in the
pathogenesis of chronic bronchial infections including bronchiectasis and cystic fibrosis
(CF). Because Pseudomonas aeruginosa frequently colonizes the respiratory tract in
bronchiectasis and CF, we examined the in vitro effects of human neutrophil elastase (HNE)
and proteinase enzymes produced by P. aeruginosa (elastase: PE; alkaline proteinase:
PAP) on the ciliary beat frequency (CBF) and ultrastructure of human nasal ciliated …

Effects of human neutrophil elastase an Pseudomonas aeruginosa proteinases on human
respiratory endothelium | CiNii Research … Effects of human neutrophil elastase an
Pseudomonas aeruginosa proteinases on human respiratory endothelium …