Effects of spaceflight on murine skeletal muscle gene expression

DL Allen, ER Bandstra, BC Harrison… - Journal of Applied …, 2009 - journals.physiology.org
… First, to better understand the gene expression changes underlying the functional … to
spaceflight, we examined the effects of spaceflight on mRNA expression in gastrocnemius muscle

[HTML][HTML] Gene Expression Profiling in Slow-Type Calf Soleus Muscle of 30 Days Space-Flown Mice

G Gambara, M Salanova, S Ciciliot, S Furlan… - PloS one, 2017 - journals.plos.org
… the global gene expression changes induced by spaceflight. For example, changes in …
gene expression adaptation involved in microgravity-induced skeletal muscle atrophy in mouse

Skeletal muscle adaptations to microgravity exposure in the mouse

BC Harrison, DL Allen, B Girten… - Journal of applied …, 2003 - journals.physiology.org
effects of microgravity exposure on skeletal muscle morphology and myosin heavy chain (MHC)
gene expression have … Spaceflight effects on single skeletal muscle fiber function in the …

[HTML][HTML] Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

D Malhan, M Yalçin, B Schoenrock, D Blottner… - npj …, 2023 - nature.com
… To assess circadian gene expression in WT mice and the impact of circadian clock alterations
in mouse skeletal muscle, we analysed time-course microarray datasets derived from WT …

Spaceflight effects on T lymphocyte distribution, function and gene expression

DS Gridley, JM Slater, X Luo-Owen… - Journal of applied …, 2009 - journals.physiology.org
… T cells in culture that were mitogen/antibody-activated and our mouse data on constitutive
gene expression are difficult because of the obviously great differences in study conditions. …

[HTML][HTML] Effects of spaceflight on the muscles of the murine shoulder

H Shen, C Lim, AG Schwartz… - The FASEB …, 2017 - ncbi.nlm.nih.gov
muscle gene expression after SF We compared changes in gene expression in 3 shoulder
muscles—… to microgravity as well as the complexity in regulation of skeletal muscle size and …

[HTML][HTML] Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space

SM Cadena, Y Zhang, J Fang, S Brachat, P Kuss… - Scientific reports, 2019 - nature.com
… between spaceflightskeletal muscles lose mass in space, we performed RNAseq analysis
on the soleus and gastrocnemius to ascertain differences in gene expression profiles in mice

Spaceflight reduces vasoconstrictor responsiveness of skeletal muscle resistance arteries in mice

JN Stabley, JM Dominguez… - Journal of Applied …, 2012 - journals.physiology.org
mRNA expression. Vessel wall thickness and maximal intraluminal diameter were unaffected
by spaceflight… -3 in smooth muscle cells as the mechanism of reduced contractile activity in …

Factors mediating spaceflight-induced skeletal muscle atrophy

PHU Lee, M Chung, Z Ren… - American Journal of …, 2022 - journals.physiology.org
… ), and IL-10 mRNA expression in skeletal muscle after 7-day bed … hindlimb immobilization
in mice lead to skeletal muscle atrophy … of mitochondrion-associated gene expression (157). …

[HTML][HTML] Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission

D Sandona, JF Desaphy, GM Camerino, E Bianchini… - PloS one, 2012 - journals.plos.org
… after space flight (see gene expression below), consistent with the knowledge that skeletal
muscle … In addition, the number of muscle fiber nuclei was reported to decrease in adult rats …