Effects of syringic acid on chronic MPTP/probenecid induced motor dysfunction, dopaminergic markers expression and neuroinflammation in C57BL/6 mice
KR Rekha, GP Selvakumar… - Biomedicine & Aging …, 2014 - Elsevier
Syringic acid (SA) is a naturally occurring O-methylated trihydroxybenzoic acid present in
wine and released as a breakdown product of malvidin, a primary plant pigment (an
anthocyanidin). In this study, the neuroprotective efficacy of syringic acid (SA) on 1-methyl-4-
phenyl-1, 2, 3, 6-tetrahydropyridine and probencid (MPTP/p) induced mouse model of PD
was investigated. The C57BL/6 mice were given 10 doses of MPTP/p for five consecutive
weeks with 3.5 day interval. Administration of MPTP/p led to reduced motor coordination …
wine and released as a breakdown product of malvidin, a primary plant pigment (an
anthocyanidin). In this study, the neuroprotective efficacy of syringic acid (SA) on 1-methyl-4-
phenyl-1, 2, 3, 6-tetrahydropyridine and probencid (MPTP/p) induced mouse model of PD
was investigated. The C57BL/6 mice were given 10 doses of MPTP/p for five consecutive
weeks with 3.5 day interval. Administration of MPTP/p led to reduced motor coordination …
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