The purpose of this study was to investigate the efficacy of COGNITIVE BEHAVIORAL GROUP TRAINING of LIFE SKILLS on MENTAL HEALTH of women with HANDICAPPED spouses in Isfahan. The study was experimental with pretest-posttest design with control group. Participants included 80 women with HANDICAPPED spouses in Isfahan who were supported by Welfare Organization. These women selected with random sampling and randomly assigned in groups. Measurement instrument was GHQ-28. The results suggested significant differences (F= 84.19, p=. 001) between the groups, indicating that COGNITIVE BEHAVIORAL GROUP TRAINING of LIFE SKILLS had significant effects on MENTAL HEALTH of women with HANDICAPPED spouses.