Electrochemical access to benzimidazolone and quinazolinone derivatives via in situ generation of isocyanates
I MaajidáTaily - Chemical Communications, 2021 - pubs.rsc.org
I MaajidáTaily
Chemical Communications, 2021•pubs.rsc.orgIsocyanates are the key intermediates for several organic transformations towards the
synthesis of diverse pharmaceutical targets. Herein, we report the development of an
oxidant-free protocol for electrochemical in situ generation of isocyanates. This strategy
highlights expedient access to benzimidazolones and quinazolinones and eliminates the
need for exogenous oxidants. Furthermore, detailed mechanistic studies provide strong
support towards our hypothesis of in situ isocyanate generation.
synthesis of diverse pharmaceutical targets. Herein, we report the development of an
oxidant-free protocol for electrochemical in situ generation of isocyanates. This strategy
highlights expedient access to benzimidazolones and quinazolinones and eliminates the
need for exogenous oxidants. Furthermore, detailed mechanistic studies provide strong
support towards our hypothesis of in situ isocyanate generation.
Isocyanates are the key intermediates for several organic transformations towards the synthesis of diverse pharmaceutical targets. Herein, we report the development of an oxidant-free protocol for electrochemical in situ generation of isocyanates. This strategy highlights expedient access to benzimidazolones and quinazolinones and eliminates the need for exogenous oxidants. Furthermore, detailed mechanistic studies provide strong support towards our hypothesis of in situ isocyanate generation.
The Royal Society of Chemistry