Elementary Ca2+ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function

SK Sonkusare, AD Bonev, J Ledoux, W Liedtke… - Science, 2012 - science.org
… (Ca 2+ ) signals (“sparklets”) in the vascular endothelium of … represent Ca 2+ influx through
single TRPV4 cation channelsTRPV4 channels in a cluster leverages the large Ca 2+ influx …

Vascular Function Mediators: TRP Channels in Endothelial and Smooth Muscle Cells

L Geng, X Ma - TRP-Mediated Signaling, 2025 - taylorfrancis.com
… formation in primary mouse intestinal mesenteric vascular ECs.… extracellular Ca2+ entry
through endothelial TRPV4 channels. … , TRPV4 is a key player in regulating pulmonary vascular

Endothelial Transient Receptor Potential Channels and Vascular Remodeling: Extracellular Ca2 + Entry for Angiogenesis, Arteriogenesis and Vasculogenesis

S Negri, P Faris, R Berra-Romani, G Guerra… - Frontiers in …, 2020 - frontiersin.org
… that endothelial Ca 2+ signals are key players in vascular … and TRPV4, which are the most
important endothelial TRPV … -regulation of endothelial TRPV4 channels plays a key role

Functional Role of TRPV4-KCa2.3 Signaling in Vascular Endothelial Cells in Normal and Streptozotocin-Induced Diabetic Rats

X Ma, J Du, P Zhang, J Deng, J Liu, FFY Lam, RA Li… - …, 2013 - Am Heart Assoc
… physical association of TRPV4 with K Ca 2.3 in the primary cultured rat … role of TRPV4-K Ca
2.3 signaling pathway in the regulation of … may allow Ca 2+ entry through TRPV4 to stimulate …

TRPV4 and the regulation of vascular tone

JA Filosa, X Yao, G Rath - Journal of cardiovascular …, 2013 - journals.lww.com
… thereby contributing to the regulation of vascular function. Thus, … Ca 2+ and K + channel
signaling. In perivascular nerves, … , TRPV4-induced Ca 2+ increases in endothelial and vascular

TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress

SA Mendoza, J Fang, DD Gutterman… - American Journal …, 2010 - journals.physiology.org
role of TRPV4 in shear stress-induced endothelial Ca 2+ entry and the potential link between
this signaling … PLA2 and TRPV4 channels regulate endothelial calcium in cerebral arteries. …

Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone

P Bagher, T Beleznai, Y Kansui… - Proceedings of the …, 2012 - National Acad Sciences
… ECs generate elementary and spatially restricted Ca 2+ events … modulating spontaneous
EC Ca 2+ events (TRPV4-associated … , this control mechanism is part of a membrane-signaling

Evidence for functional and dynamic microcompartmentation of Cav-1/TRPV4/KCa in caveolae of endothelial cells

S Goedicke-Fritz, A Kaistha, M Kacik, S Markert… - European journal of cell …, 2015 - Elsevier
… The arterial endothelium is critically involved in the regulation of … , which are involved in Ca
2+ translocation, EDHF-signaling … with TRPV4 and K Ca channels in human endothelial cells, …

Vascular smooth muscle TRPV4 (transient receptor potential vanilloid family member 4) channels regulate vasoconstriction and blood pressure in obesity

Y Zhu, Y Chu, S Wang, J Tang, H Li, L Feng, F Yu… - …, 2023 - Am Heart Assoc
… to vascular function and blood pressure regulation in … endothelial TRPV4 due to their
different features of [Ca 2+ ] i … SMC TRPV4 channels to U46619-induced Ca 2+ entry into

TRP channel Ca2+ sparklets: fundamental signals underlying endothelium-dependent hyperpolarization

MN Sullivan, S Earley - American Journal of Physiology …, 2013 - journals.physiology.org
regulation and physiological significance of TRPV4 Ca 2+ sparklets in the vascular endothelium
… first evidence demonstrating that most TRPV4 channels in primary endothelial cells are “…