The effects of amino acid insertions and deletions (InDels) remain a rather under-explored
area of structural biology. These variations oftentimes are the cause of numerous disease
phenotypes. In spite of this, research to study InDels and their structural significance remains
limited, primarily due to a lack of experimental information and computational methods. In
this work, we fill this gap by modeling InDels computationally; we investigate the rigidity
differences between the wildtype and a mutant variant with one or more InDels. Further, we …

The effects of amino acid insertions and deletions (InDels) remain a rather under-explored
area of structural biology. These variations oftentimes are the cause of numerous disease
phenotypes. In spite of this, research to study InDels and their structural significance remains
limited, primarily due to a lack of experimental information and computational methods. In
this work, we fill this gap by modeling InDels computationally; we investigate the rigidity
differences between the wildtype and a mutant variant with one or more InDels. Further, we …