Elucidation of the substrate specificity, kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum
V Bulusu, B Srinivasan, MP Bopanna… - Biochimica et Biophysica …, 2009 - Elsevier
Adenylosuccinate lyase (ASL) catalyzes two distinct but chemically similar reactions in
purine biosynthesis. The first, exclusive to the de novo pathway involves the cleavage of 5-
aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) to 5-aminoimidazole-4-
carboxamide ribonucleotide (AICAR) and fumarate and the second common to both de novo
and the salvage pathways involves the cleavage of succinyl-adenosine monophosphate
(SAMP) to AMP and fumarate. A detailed kinetic and catalytic mechanism of the recombinant …
purine biosynthesis. The first, exclusive to the de novo pathway involves the cleavage of 5-
aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) to 5-aminoimidazole-4-
carboxamide ribonucleotide (AICAR) and fumarate and the second common to both de novo
and the salvage pathways involves the cleavage of succinyl-adenosine monophosphate
(SAMP) to AMP and fumarate. A detailed kinetic and catalytic mechanism of the recombinant …
Elucidation of the substrate specificity, kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum.
VB Vinay Bulusu, BS Bharath Srinivasan, MP Bopanna… - 2009 - cabidigitallibrary.org
Adenylosuccinate lyase (ASL) catalyzes two distinct but chemically similar reactions in
purine biosynthesis. The first, exclusive to the de novo pathway involves the cleavage of 5-
aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) to 5-aminoimidazole-4-
carboxamide ribonucleotide (AICAR) and fumarate and the second common to both de novo
and the salvage pathways involves the cleavage of succinyl-adenosine monophosphate
(SAMP) to AMP and fumarate. A detailed kinetic and catalytic mechanism of the recombinant …
purine biosynthesis. The first, exclusive to the de novo pathway involves the cleavage of 5-
aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) to 5-aminoimidazole-4-
carboxamide ribonucleotide (AICAR) and fumarate and the second common to both de novo
and the salvage pathways involves the cleavage of succinyl-adenosine monophosphate
(SAMP) to AMP and fumarate. A detailed kinetic and catalytic mechanism of the recombinant …
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