Rapid emergence of multidrug co-resistant AmpC β-Lactamase and Carbapenamase Enteric Isolates in Abeokuta, Nigeria was investigated. A total of 426 faecal samples was obtained and tested for AmpC ß-lactamases using Inhibitor based test method and carbapenamase production. Their antibiotics susceptibility to various commonly used antibiotics was evaluated accordingly. Only 5 (45.5%) express AmpC beta-lactamase among hospital patients while 17/59 (63.0%) from community residents. Carbapenamase producing ESBL isolates among the hospital patients shows 0.76% rate compare to 3.3% recorded among the community residents. High resistant of 100% was recorded in some enteric isolates such as Klebsiella spp, Pseudomonas spp and Proteus spp to ampicillin while 81.0%, 67.5% and 63.0% were resistant to ceftazidime, azithromycin and cefuroxime (MIC< 8). Proliferation of multi-drug resistance AmpC beta-lactamase and carbapenamse strains may become predominant in our health care facilities and in the community as a result of the indiscriminate use of antimicrobial agents and fecal carriage among the people who serve as risk factor, and thereby making formulation of public health guidelines unachievable.