Mammalian genomes encode tens of thousands of long-noncoding RNAs (lncRNAs), which
are capable of interactions with DNA, RNA and protein molecules, thereby enabling a
variety of transcriptional and post-transcriptional regulatory activities. Strikingly, about 40%
of lncRNAs are expressed specifically in the brain with precisely regulated temporal and
spatial expression patterns. In stark contrast to the highly conserved repertoire of protein-
coding genes, thousands of lncRNAs have newly appeared during primate nervous system …