Enantiomeric Recognition of d- and l-Lactate by CEST with the Aid of a Paramagnetic Shift Reagent
L Zhang, AF Martins, P Zhao, M Tieu… - Journal of the …, 2017 - ACS Publications
A previous report demonstrated that EuDO3A could be used as an NMR shift reagent for
imaging extracellular lactate produced by cancer cells using CEST imaging. In this work, a
series of heptadentate macrocyclic YbDO3A-trisamide complexes with δ-chiral carbons in
the three pendant side-arms were examined as shift reagents for lactate detection. High
resolution 1H NMR spectra and DFT calculations provided evidence for the formation of
stereoselective lactate· YbDO3A-trisamide complexes each with a different CEST signature …
imaging extracellular lactate produced by cancer cells using CEST imaging. In this work, a
series of heptadentate macrocyclic YbDO3A-trisamide complexes with δ-chiral carbons in
the three pendant side-arms were examined as shift reagents for lactate detection. High
resolution 1H NMR spectra and DFT calculations provided evidence for the formation of
stereoselective lactate· YbDO3A-trisamide complexes each with a different CEST signature …
[引用][C] Enantiomeric Recognition of d-and l-Lactate by CEST with the Aid of a Paramagnetic Shift Reagent
Z Lei, Z Piyu, T Michael, EG David, PI Carlos, SA Dean - 2017
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