Enantioselective 4-hydroxylation of phenols under chiral organoiodine (I/III) catalysis
K Muniz, L Fra - Synthesis, 2017 - thieme-connect.com
K Muniz, L Fra
Synthesis, 2017•thieme-connect.comA procedure for the intermolecular enantioselective dearomatization of phenols under chiral
(I/III) catalysis is reported. This protocol employs 3-chloroperoxybenzoic acid (m-CPBA) as
the terminal oxidant together with a defined C 2-symmetric aryl iodide as the effective
organocatalyst. This enantioselective reaction proceeds with complete selectivity under mild
conditions and enables the hydroxylative dearomatization of a number of phenols to give the
corresponding p-quinol products with up to 50% ee.
(I/III) catalysis is reported. This protocol employs 3-chloroperoxybenzoic acid (m-CPBA) as
the terminal oxidant together with a defined C 2-symmetric aryl iodide as the effective
organocatalyst. This enantioselective reaction proceeds with complete selectivity under mild
conditions and enables the hydroxylative dearomatization of a number of phenols to give the
corresponding p-quinol products with up to 50% ee.
A procedure for the intermolecular enantioselective dearomatization of phenols under chiral (I/III) catalysis is reported. This protocol employs 3-chloroperoxybenzoic acid (m-CPBA) as the terminal oxidant together with a defined C 2-symmetric aryl iodide as the effective organocatalyst. This enantioselective reaction proceeds with complete selectivity under mild conditions and enables the hydroxylative dearomatization of a number of phenols to give the corresponding p-quinol products with up to 50% ee.
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