Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease
Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) have well-documented protective effects
against obesity-induced insulin resistance and hepatic steatosis. Here, we investigated the
effects of endogenous n-3 PUFAs on diet-induced fatty liver disease using fat-1 transgenic
mice (fat-1) capable of converting n-6 to n-3 PUFAs. Wild-type (WT) and fat-1 mice were
maintained on a high-fat diet (HFD) for 5months. HFD-induced weight gain and fatty liver
were more prominent in WT mice than fat-1 mice. Histological analysis indicated that WT …
against obesity-induced insulin resistance and hepatic steatosis. Here, we investigated the
effects of endogenous n-3 PUFAs on diet-induced fatty liver disease using fat-1 transgenic
mice (fat-1) capable of converting n-6 to n-3 PUFAs. Wild-type (WT) and fat-1 mice were
maintained on a high-fat diet (HFD) for 5months. HFD-induced weight gain and fatty liver
were more prominent in WT mice than fat-1 mice. Histological analysis indicated that WT …
Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease.
KEH Kim EunHee, BJS Bae JinSik, HKB Hahm KiBaik… - 2012 - cabidigitallibrary.org
Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) have well-documented protective effects
against obesity-induced insulin resistance and hepatic steatosis. Here, we investigated the
effects of endogenous n-3 PUFAs on diet-induced fatty liver disease using fat-1 transgenic
mice (fat-1) capable of converting n-6 to n-3 PUFAs. Wild-type (WT) and fat-1 mice were
maintained on a high-fat diet (HFD) for 5 months. HFD-induced weight gain and fatty liver
were more prominent in WT mice than fat-1 mice. Histological analysis indicated that WT …
against obesity-induced insulin resistance and hepatic steatosis. Here, we investigated the
effects of endogenous n-3 PUFAs on diet-induced fatty liver disease using fat-1 transgenic
mice (fat-1) capable of converting n-6 to n-3 PUFAs. Wild-type (WT) and fat-1 mice were
maintained on a high-fat diet (HFD) for 5 months. HFD-induced weight gain and fatty liver
were more prominent in WT mice than fat-1 mice. Histological analysis indicated that WT …