Endoplasmic reticulum-mitochondria miscommunication is an early and causal trigger of hepatic insulin resistance and steatosis
Background & Aims Hepatic insulin resistance in obesity and type 2 diabetes was recently
associated with endoplasmic reticulum (ER)-mitochondria miscommunication. These contact
sites (mitochondria-associated membranes: MAMs) are highly dynamic and involved in
many functions; however, whether MAM dysfunction plays a causal role in hepatic insulin
resistance and steatosis is not clear. Thus, we aimed to determine whether and how
organelle miscommunication plays a role in the onset and progression of hepatic metabolic …
associated with endoplasmic reticulum (ER)-mitochondria miscommunication. These contact
sites (mitochondria-associated membranes: MAMs) are highly dynamic and involved in
many functions; however, whether MAM dysfunction plays a causal role in hepatic insulin
resistance and steatosis is not clear. Thus, we aimed to determine whether and how
organelle miscommunication plays a role in the onset and progression of hepatic metabolic …
以上显示的是最相近的搜索结果。 查看全部搜索结果