Endothelial cell-specific deletion of a microRNA accelerates atherosclerosis
Background and aims Chronic vascular endothelial inflammation predisposes to
atherosclerosis; however, the cell-autonomous roles for endothelial-expressing microRNAs
(miRNAs) are poorly understood in this process. MiR-181b is expressed in several cellular
constituents relevant to lesion formation. The aim of this study is to examine the role of
genetic deficiency of the miR-181b locus in endothelial cells during atherogenesis. Methods
and Results Using a proprotein convertase subtilisin/kexin type 9 (PCSK9)-induced …
atherosclerosis; however, the cell-autonomous roles for endothelial-expressing microRNAs
(miRNAs) are poorly understood in this process. MiR-181b is expressed in several cellular
constituents relevant to lesion formation. The aim of this study is to examine the role of
genetic deficiency of the miR-181b locus in endothelial cells during atherogenesis. Methods
and Results Using a proprotein convertase subtilisin/kexin type 9 (PCSK9)-induced …
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