Engineering ER-stress dependent non-conventional mRNA splicing
The endoplasmic reticulum (ER) protein folding capacity is balanced with the protein folding
burden to prevent accumulation of un-or misfolded proteins. The ER membrane-resident
kinase/RNase Ire1 maintains ER protein homeostasis through two fundamentally distinct
processes. First, Ire1 can initiate a transcriptional response through a non-conventional
mRNA splicing reaction to increase the ER folding capacity. Second, Ire1 can decrease the
ER folding burden through selective mRNA decay. In Saccharomyces cerevisiae and …
burden to prevent accumulation of un-or misfolded proteins. The ER membrane-resident
kinase/RNase Ire1 maintains ER protein homeostasis through two fundamentally distinct
processes. First, Ire1 can initiate a transcriptional response through a non-conventional
mRNA splicing reaction to increase the ER folding capacity. Second, Ire1 can decrease the
ER folding burden through selective mRNA decay. In Saccharomyces cerevisiae and …
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