[HTML][HTML] Engineering spatial-organized cardiac organoids for developmental toxicity testing

P Hoang, A Kowalczewski, S Sun, TS Winston… - Stem Cell Reports, 2021 - cell.com
Emerging technologies in stem cell engineering have produced sophisticated organoid
platforms by controlling stem cell fate via biomaterial instructive cues. By micropatterning
and differentiating human induced pluripotent stem cells (hiPSCs), we have engineered
spatially organized cardiac organoids with contracting cardiomyocytes in the center
surrounded by stromal cells distributed along the pattern perimeter. We investigated how
geometric confinement directed the structural morphology and contractile functions of the …

Engineering spatial-organized cardiac organoids for developmental toxicity testing

Z Ma, P Hoang - US Patent App. 17/837,697, 2022 - Google Patents
NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl) phenyl]-2-[3-(4-ethyl-5-
ethylsulfanyl-1, 2, 4-triazol-3-yl) piperidin-1-yl] acetamide Chemical compound CCN1C
(SCC)= NN= C1C1CN (CC (= O) NC= 2C (= CC= C (C= 2) C (F)(F) F) Cl) CCC1
NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 claims description 4
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