Recognition of the molecular events that lead to enhanced cell death is vital to understand
the developmental cerebellar defects under hypothyroidism. Though neurotrophins promote
the survival and development of neurons in the cerebellum, but the mechanism of their
insufficiency mediated cell loss under hypothyroidism is unknown. Here in developmental
hypothyroid rat model we report that hypothyroidism induced neuronal loss involve down
regulation of neurotrophic survival signaling and increased truncation of the receptor …