Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
… but readily undergoes transport into cells through GLUT1, a … to more efficient treatments
and better cell health. Minimizing … a host of chemical agents and effects can lead to membrane

Membrane-disrupting molecules as therapeutic agents: a cautionary note

SL Regen - JACS Au, 2020 - ACS Publications
… In previous mechanistic studies with model systems, we have shown that the common
membrane-disruptive agent Triton X-100 can destroy the integrity of compact lipid bilayers (eg, …

Effect of membrane fouling on transport of organic contaminants in NF/RO membrane applications

P Xu, JE Drewes, TU Kim, C Bellona, G Amy - Journal of Membrane …, 2006 - Elsevier
Membrane fouling also resulted in an increased adsorption capacity and reduced mass
transport through partitioning and diffusion of solutes across the membrane. These effects led to …

The design and synthesis of polymers for eukaryotic membrane disruption

N Murthy, JR Robichaud, DA Tirrell, PS Stayton… - Journal of controlled …, 1999 - Elsevier
… molecules which can enhance the transport of endocytosed … of membrane-disruptive polymers
which could enhance the … result in more efficient membrane disruptive agents. While the …

[HTML][HTML] Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

L Lin, J Chi, Y Yan, R Luo, X Feng, Y Zheng… - … Pharmaceutica Sinica B, 2021 - Elsevier
Membrane-disruptive peptides/peptidomimetics (MDPs) are … mechanism through the physical
disruption of cell membranes, … adjuvants to enhance the therapeutic effects of other agents. …

Plasma membrane disruption: repair, prevention, adaptation

PL McNeil, RA Steinhardt - Annual review of cell and …, 2003 - annualreviews.org
… Moreover, treatingfibroblasts with agents that reduce membrane tension, for
examplesurface-active … Cell surfacearea can be increased by exocytotic delivery of internal …

Pharmaceuticals, personal care products and endocrine disrupting agents in the environment–a review

FA Caliman, M Gavrilescu - CLEAN–Soil, Air, Water, 2009 - Wiley Online Library
… for hygienic use detected in waters have increased. Several of … Ionic, water soluble ECDs;
increased transport and dispersion… The removal efficiency of EDCs using membranes depends …

[HTML][HTML] Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery

MA Deli - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2009 - Elsevier
transport routes exist in these barriers, which potentially can be exploited for enhancing drug
… Similarly to transmembrane TJ proteins, some of the AJ proteins can bind infectious agents. …

Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides

N Murthy, J Campbell, N Fausto, AS Hoffman… - Journal of Controlled …, 2003 - Elsevier
… , and become membrane destabilizing. This enhances transport of active proteins or DNA …
serve as a pH-responsive, endosome-disrupting agent to enhance non-viral gene transfection …

In vitro characterization of the anticancer activity of membrane-active cationic peptides. I. Peptide-mediated cytotoxicity and peptide-enhanced cytotoxic activity of …

SA Johnstone, K Gelmon, LD Mayer… - Anti-cancer drug …, 2000 - ingentaconnect.com
… We believe these agents have potential as novel, membrane-… that affect transport of other
therapeutic agents. This has … Agents that promote disruption of plasma membranes can be …