Enzyme informatics
RG Alderson, L De Ferrari, L Mavridis… - Current topics in …, 2012 - ingentaconnect.com
… understanding of enzyme structure and dynamics, we are only beginning to be able to
design novel enzymes. One can now begin to trace the functional evolution of enzymes using …
design novel enzymes. One can now begin to trace the functional evolution of enzymes using …
[PDF][PDF] Enzyme informatics
… As enzymes are involved in all steps of metabolic … of enzymes is important for drug design
like design of enzyme inhibitors which has been a mainstay of molecular design. Enzyme …
like design of enzyme inhibitors which has been a mainstay of molecular design. Enzyme …
Enzyme kinetics informatics: from instrument to browser
N Swainston, M Golebiewski, HL Messiha… - The FEBS …, 2010 - Wiley Online Library
A limited number of publicly available resources provide access to enzyme kinetic parameters.
These have been compiled through manual data mining of published papers, not from …
These have been compiled through manual data mining of published papers, not from …
Modelling and informatics in the analysis of P. falciparum DHFR enzyme inhibitors
L Adane, PV Bharatam - Current medicinal chemistry, 2008 - ingentaconnect.com
… and informatics studies to P. falciparum DHFR enzyme. Modelling studies on DHFR … , most
of the information regarding the structure and enzyme-inhibitor interactions of this enzyme are …
of the information regarding the structure and enzyme-inhibitor interactions of this enzyme are …
Functional and informatics analysis enables glycosyltransferase activity prediction
M Yang, C Fehl, KV Lees, EK Lim, WA Offen… - Nature chemical …, 2018 - nature.com
… Strategy for functional profiling of an enzyme superfamily To date, informatics or computational
strategies for predicting GT1 enzyme activity have made only limited progress, as further …
strategies for predicting GT1 enzyme activity have made only limited progress, as further …
[图书][B] Biomacromolecules: Introduction to structure, function and informatics
CS Tsai - 2007 - books.google.com
… The following chapters discuss biomolecular interactions, enzyme action, gene transmission,
signal transduction, and biomacromolecular informatics. The author concludes with …
signal transduction, and biomacromolecular informatics. The author concludes with …
Interrogating the druggable genome with structural informatics
K Hambly, J Danzer, S Muskal, DA Debe - Molecular diversity, 2006 - Springer
… Target Informatics Platform (TIP), a novel structural informatics … Our analysis underscores
the utility of a structural informatics … -converting enzyme inhibitors on bradykinin metabolism in …
the utility of a structural informatics … -converting enzyme inhibitors on bradykinin metabolism in …
Biopharmaceutical Informatics: supporting biologic drug development via molecular modelling and informatics
S Kumar, NV Plotnikov, JC Rouse… - Journal of Pharmacy …, 2018 - academic.oup.com
… Informatics by building a strategic framework of computational biophysical tools and informatics
… Non-enzymatic spontaneous chemical degradation of biologic drug products during …
… Non-enzymatic spontaneous chemical degradation of biologic drug products during …
[HTML][HTML] Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)
RT Cameron, RG Coleman, JP Day, KC Yalla… - Biochemical …, 2013 - Elsevier
… cAMP hydrolyzing phosphodiesterase 4 (PDE4) enzyme family, which has been implicated
in … The fact that all PDE4 enzymes have been highly conserved over evolution suggests that …
in … The fact that all PDE4 enzymes have been highly conserved over evolution suggests that …
Structural informatics: chemogenomics in silico
DA Debe, KP Hambly, JF Danzer - … ‐based Approaches to Drug …, 2006 - books.google.com
… At Eidogen-Sertanty, we have developed a structural informatics database that utilizes …
human enzyme close off a portion of the binding pocket that is accessible in the fungal enzyme, …
human enzyme close off a portion of the binding pocket that is accessible in the fungal enzyme, …