Enzyme logic gate associated with a single responsive microparticle: scaling biocomputing to microsize systems
… In the present work we used a single pH-sensitive microparticle to report on the pH
changes generated by an enzyme logic system. … The present work opens the way to
enzyme logic networks associated with single responsive microparticles dramatically
miniaturizing biocomputing systems. We anticipate that such miniaturized enzyme logic
gates processing biochemical signals will find numerous analytical and biomedical
applications, facilitate decision-making in connection to autonomous feedback-loop drug-delivery …
changes generated by an enzyme logic system. … The present work opens the way to
enzyme logic networks associated with single responsive microparticles dramatically
miniaturizing biocomputing systems. We anticipate that such miniaturized enzyme logic
gates processing biochemical signals will find numerous analytical and biomedical
applications, facilitate decision-making in connection to autonomous feedback-loop drug-delivery …
A microsize biocomputing system based on enzyme logic processing biochemical signals was developed. Optical transduction of pH signals generated in situ by the enzyme OR logic gate was achieved with the use of a single optode microparticle.
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