TJs maintain the epithelial barrier by regulating paracellular permeability. Since TJs are
under dynamically fluctuating intercellular tension, cells must continuously survey and repair
any damage. However, the underlying mechanisms allowing cells to sense TJ damage and
repair the barrier are not yet fully understood. Here, we showed that proteinases play an
important role in the maintenance of the epithelial barrier. At TJ break sites, EpCAM–claudin-
7 complexes on the basolateral membrane become accessible to apical membrane …

EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight
junction barrier. | CiNii Research … EpCAM proteolysis and release of complexed claudin-7
repair and maintain the tight junction barrier. … タイトル EpCAM proteolysis and release of
complexed claudin-7 repair and maintain the tight junction barrier. …