Epigenetic changes induced by air toxics: formaldehyde exposure alters miRNA expression profiles in human lung cells

JE Rager, L Smeester, I Jaspers… - Environmental health …, 2011 - ehp.niehs.nih.gov
Background Exposure to formaldehyde, a known air toxic, is associated with cancer and
lung disease. Despite the adverse health effects of formaldehyde, the mechanisms
underlying formaldehyde-induced disease remain largely unknown. Research has
uncovered microRNAs (miRNAs) as key posttranscriptional regulators of gene expression
that may influence cellular disease state. Although studies have compared different miRNA
expression patterns between diseased and healthy tissue, this is the first study to examine …
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