[HTML][HTML] Epigenetic landscape of Parkinson's disease: emerging role in disease mechanisms and therapeutic modalities
NA Kaidery, S Tarannum, B Thomas - Neurotherapeutics, 2013 - Elsevier
Parkinson's disease (PD) is a complex multifactorial disorder marked by extensive system-
wide pathology, including a substantial loss of nigrostriatal dopaminergic neurons. The
etiology of PD remains elusive, but there is considerable evidence that, in addition to well-
defined genetic mechanisms environmental factors play a crucial role in disease
pathogenesis. How the environment might influence the genetic factors and contribute to
disease development and progression remains unclear. In recent years, epigenetic …
wide pathology, including a substantial loss of nigrostriatal dopaminergic neurons. The
etiology of PD remains elusive, but there is considerable evidence that, in addition to well-
defined genetic mechanisms environmental factors play a crucial role in disease
pathogenesis. How the environment might influence the genetic factors and contribute to
disease development and progression remains unclear. In recent years, epigenetic …
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