Epithelial ovarian cancer (OvCa) is associated with high mortality and, as the majority (>
75%) of women with OvCa have metastatic disease at the time of diagnosis, rates of survival
have not changed appreciably over 30 years. A mechanistic understanding of OvCa
initiation and progression is hindered by the complexity of genetic and/or environmental
initiating events and lack of clarity regarding the cell (s) or tissue (s) of origin. Metastasis of
OvCa involves direct extension or exfoliation of cells and cellular aggregates into the …

Epithelial ovarian cancer (OvCa) is associated with high mortality and, as the majority (>
75%) of women with OvCa have metastatic disease at the time of diagnosis, rates of survival
have not changed appreciably over 30 years. A mechanistic understanding of OvCa
initiation and progression is hindered by the complexity of genetic and/or environmental
initiating events and lack of clarity regarding the cell (s) or tissue (s) of origin. Metastasis of
OvCa involves direct extension or exfoliation of cells and cellular aggregates into the …