Intestinal epithelial cells (IECs) are at the forefront of host-pathogen interactions,
coordinating a cascade of immune responses to protect against pathogens. Here we show
that IEC-intrinsic vitamin A signaling restricts pathogen invasion early in the infection and
subsequently activates immune cells to promote pathogen clearance. Mice blocked for
retinoic acid receptor (RAR) signaling selectively in IECs (stopΔIEC) showed higher
Salmonella burden in colonic tissues early in the infection that associated with higher …

Intestinal epithelial cells (IECs) are at the forefront of host-pathogen interactions,
coordinating a cascade of immune responses to confer protection against pathogens. Here
we show that IEC-intrinsic vitamin A signaling restricts pathogen invasion early in the
infection and subsequently activates immune cells to promote pathogen clearance. Mice
blocked for retinoic acid receptor (RAR) signaling selectively in IECs (stopΔIEC) showed
significantly higher Salmonella burden in colonic tissues early in the infection associated …