Error propagation in constraint‐based modeling of Chinese hamster ovary cells
Chinese hamster ovary (CHO) cells are the most popular mammalian cell factories for the
production of glycosylated biopharmaceuticals. To further increase titer and productivity and
ensure product quality, rational system‐level engineering strategies based on constraint‐
based metabolic modeling, such as flux balance analysis (FBA), have gained strong interest.
However, the quality of FBA predictions depends on the accuracy of the experimental input
data, especially on the exchange rates of extracellular metabolites. Yet, it is not standard …
production of glycosylated biopharmaceuticals. To further increase titer and productivity and
ensure product quality, rational system‐level engineering strategies based on constraint‐
based metabolic modeling, such as flux balance analysis (FBA), have gained strong interest.
However, the quality of FBA predictions depends on the accuracy of the experimental input
data, especially on the exchange rates of extracellular metabolites. Yet, it is not standard …
[PDF][PDF] Error propagation in constraint-based modeling of Chinese hamster ovary cells
Chinese hamster ovary (CHO) cells are the most popular mammalian cell factories for the
production of glycosylated biopharmaceuticals. To further increase titer and productivity and
ensure product quality, rational system-level engineering strategies based on constraint-
based metabolic modeling, such as flux balance analysis (FBA), have gained strong interest.
However, the quality of FBA predictions depends on the accuracy of the experimental input
data, especially on the exchange rates of extracellular metabolites. Yet, it is not standard …
production of glycosylated biopharmaceuticals. To further increase titer and productivity and
ensure product quality, rational system-level engineering strategies based on constraint-
based metabolic modeling, such as flux balance analysis (FBA), have gained strong interest.
However, the quality of FBA predictions depends on the accuracy of the experimental input
data, especially on the exchange rates of extracellular metabolites. Yet, it is not standard …
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