[HTML][HTML] Erythropoietin-regulated oxidative stress negatively affects enucleation during terminal erythropoiesis
Highlights•Erythropoietin (Epo) induces reactive oxygen species (ROS) production in early-
stage erythroblasts.•Oxidative status is correlated with CD71 expression and the uptake of
iron and transferrin.•The ROS level decreases in the late stages of terminal
erythropoiesis.•The ROS scavenger promotes enucleation.Differentiating erythroblasts are
exposed to an oxidative environment. The dynamics of oxidative status during terminal
erythropoiesis and how they affect cell differentiation in response to erythropoietin (Epo) are …
stage erythroblasts.•Oxidative status is correlated with CD71 expression and the uptake of
iron and transferrin.•The ROS level decreases in the late stages of terminal
erythropoiesis.•The ROS scavenger promotes enucleation.Differentiating erythroblasts are
exposed to an oxidative environment. The dynamics of oxidative status during terminal
erythropoiesis and how they affect cell differentiation in response to erythropoietin (Epo) are …
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