Essential function of dicer in resolving DNA damage in the rapidly dividing cells of the developing and malignant cerebellum
V Swahari, A Nakamura, J Baran-Gale, I Garcia… - Cell reports, 2016 - cell.com
Maintenance of genomic integrity is critical during neurodevelopment, particularly in rapidly
dividing cerebellar granule neuronal precursors that experience constitutive replication-
associated DNA damage. As Dicer was recently recognized to have an unexpected function
in the DNA damage response, we examined whether Dicer was important for preserving
genomic integrity in the developing brain. We report that deletion of Dicer in the developing
mouse cerebellum resulted in the accumulation of DNA damage leading to cerebellar …
dividing cerebellar granule neuronal precursors that experience constitutive replication-
associated DNA damage. As Dicer was recently recognized to have an unexpected function
in the DNA damage response, we examined whether Dicer was important for preserving
genomic integrity in the developing brain. We report that deletion of Dicer in the developing
mouse cerebellum resulted in the accumulation of DNA damage leading to cerebellar …
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