[HTML][HTML] Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis

M Shimada, T Goshima, H Matsuo, Y Johmura… - Nature …, 2016 - nature.com
… in the culminated activation of Aurora B at centromeres, triggering activation of … Aurora
B-mediated H2AX-pS121 could provide a molecular scaffold for Aurora B autoactivation circuitry

[HTML][HTML] Aurora B twists on histones for activation

M Shimada, M Nakanishi - Cell Cycle, 2016 - Taylor & Francis
… , we successfully demonstrate that H2AX-pS121 predominantly localizes at mitotic … results
indicate that Aurora B-mediated H2AX-pS121 facilitates Aurora B autoactivation circuitry at …

[HTML][HTML] The ins and outs of Aurora B inner centromere localization

S Hindriksen, SMA Lens, MA Hadders - Frontiers in cell and …, 2017 - frontiersin.org
… The mitotic kinase Aurora B plays a crucial role in this … on Aurora B activity and thus involve
multiple feedback circuits. In … of the SAH affected Aurora B-mediated phosphorylation of outer …

[HTML][HTML] Aurora B tension sensing mechanisms in the kinetochore ensure accurate chromosome segregation

SL McVey, JK Cosby, NJ Nannas - International Journal of Molecular …, 2021 - mdpi.com
… for translating mechanical force into Aurora B-mediated biochemical signals that regulate …
Aurora B regulates many aspects of mitosis [37], but it plays a critical role in sensing the tension…

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis

R Honda, R Korner, EA Nigg - Molecular biology of the cell, 2003 - Am Soc Cell Biol
… Our functional studies confirm the notion that Aurora B is critical for multiple aspects of mitotic
progression. Expression of the kinase-deficient mutant exerted a dominant-negative effect …

Priming chromatin for segregation: functional roles of mitotic histone modifications

ML Schmitz, JMG Higgins, M Seibert - Cell Cycle, 2020 - Taylor & Francis
… Centromeres play a crucial role during mitosis as they are hubs of … B auto-activation and
Haspin recruitment [Citation40]. After … In addition, Aurora B-mediated restriction of phosphatases …

[HTML][HTML] Aurora kinases: novel therapy targets in cancers

A Tang, K Gao, L Chu, R Zhang, J Yang, J Zheng - Oncotarget, 2017 - ncbi.nlm.nih.gov
… C (AURKC), are essential kinases for cell division via regulating mitosis especially the …
physiological functions of Aurora kinases in mitosis, then describe the oncogenic role of Aurora

γ-H2AX is present at mouse meiotic kinetochores

A Guajardo, A Viera, MT Parra, MM Valdivia, JS Rufas… - bioRxiv, 2020 - biorxiv.org
… In this study, we have analyzed the distribution of γ-H2AX during male mouse meiosis by
immunofluorescence on spread and squashed spermatocytes. We have found that γ-H2AX …

[HTML][HTML] Aurora kinases in ovarian cancer

JA Pérez-Fidalgo, V Gambardella, B Pineda… - ESMO open, 2020 - Elsevier
Aurora kinases (AURK) are key regulators of the mitotic spindle formation. AURK is frequently
Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis

TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis

N Suzuki, Y Johmura, TW Wang, T Migita, W Wu… - Autophagy, 2021 - Taylor & Francis
… factor EB) axis plays an essential role in this process through upregulating basal … autophagy
is summarized as a schematic (Fig. S7D). The essential role of FBXO22 in hormesis was …