Endothelial nitric oxide synthase (eNOS) is essential for neovascularization. Here we show
that the impaired neovascularization in mice lacking eNOS is related to a defect in
progenitor cell mobilization. Mice deficient in eNOS (Nos3−/−) show reduced vascular
endothelial growth factor (VEGF)-induced mobilization of endothelial progenitor cells (EPCs)
and increased mortality after myelosuppression. Intravenous infusion of wild-type progenitor
cells, but not bone marrow transplantation, rescued the defective neovascularization of …

Erratum: Essential role of endothelial nitric oxide synthase for mobilization of stem and
progenitor cells - Document - Gale OneFile: Health and Medicine …