A physiologically based pharmacokinetic (PB-PK) model for CHCl3 has been used to
prepare estimates of the probability that human populations exposed to low levels of CHCl3
will develop liver tumors similar to those seen in rodent bioassays. The PB-PK model for
CHCl3 was based on a model reported earlier by Corley et al.(1990), but this model differed
from that of Corley et al. in that it was also capable of describing a pharmacodynamic
endpoint: induction of cytotoxicity in the liver of CHCl3-exposed animals produced by …

Estimating the risk of liver cancer associated with human exposures to chloroform using
physiologically based pharmacokinetic modeling [Erratum to document cited in CA114(3):19273k]
| Health & Environmental Research Online (HERO) | US EPA … Estimating the risk of liver
cancer associated with human exposures to chloroform using physiologically based
pharmacokinetic modeling [Erratum to document cited in CA114(3):19273k] …