[HTML][HTML] Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal
PH Puhakka, NCR Te Moller, IO Afara… - Osteoarthritis and …, 2015 - Elsevier
Osteoarthritis and Cartilage, 2015•Elsevier
Objective The aim was to investigate the applicability of multivariate analysis of optical
coherence tomography (OCT) information for determining structural integrity, composition
and mechanical properties of articular cartilage. Design Equine osteochondral samples (N=
65) were imaged with OCT, and their total attenuation and backscattering coefficients (μ t
and μ b) were measured. Subsequently, the Mankin score, optical density (OD) describing
the fixed charge density, light absorbance in amide I region (A amide), collagen orientation …
coherence tomography (OCT) information for determining structural integrity, composition
and mechanical properties of articular cartilage. Design Equine osteochondral samples (N=
65) were imaged with OCT, and their total attenuation and backscattering coefficients (μ t
and μ b) were measured. Subsequently, the Mankin score, optical density (OD) describing
the fixed charge density, light absorbance in amide I region (A amide), collagen orientation …
Objective
The aim was to investigate the applicability of multivariate analysis of optical coherence tomography (OCT) information for determining structural integrity, composition and mechanical properties of articular cartilage.
Design
Equine osteochondral samples (N = 65) were imaged with OCT, and their total attenuation and backscattering coefficients (μt and μb) were measured. Subsequently, the Mankin score, optical density (OD) describing the fixed charge density, light absorbance in amide I region (Aamide), collagen orientation, permeability, fibril network modulus (Ef) and non-fibrillar matrix modulus (Em) of the samples were determined. Partial least squares (PLS) regression model was calculated to predict tissue properties from the OCT signals of the samples.
Results
Significant correlations between the measured and predicted mean collagen orientation (R2 = 0.75, P < 0.0001), permeability (R2 = 0.74, P < 0.0001), mean OD (R2 = 0.73, P < 0.0001), Mankin scores (R2 = 0.70, P < 0.0001), Em (R2 = 0.50, P < 0.0001), Ef (R2 = 0.42, P < 0.0001), and Aamide (R2 = 0.43, P < 0.0001) were obtained. Significant correlation was also found between μb and Ef (ρ = 0.280, P = 0.03), but not between μt and any of the determined properties of articular cartilage (P > 0.05).
Conclusion
Multivariate analysis of OCT signal provided good estimates for tissue structure, composition and mechanical properties. This technique may significantly enhance OCT evaluation of articular cartilage integrity, and could be applied, for example, in delineation of degenerated areas around cartilage injuries during arthroscopic repair surgery.
Elsevier
以上显示的是最相近的搜索结果。 查看全部搜索结果