Estrogen receptor activation and cardioprotection in ischemia reperfusion injury
AM Deschamps, E Murphy, J Sun - Trends in cardiovascular medicine, 2010 - Elsevier
Premenopausal females have a comparably lower incidence of cardiovascular disease than
their male counterparts. Although estrogen and activation of estrogen receptors (ERs) have
been found to contribute to female protection, the complex mechanisms involved are
unclear. Besides altering gene transcription, estrogen could elicit its cardioprotective effect
via ER-mediated nongenomic signaling pathways. In addition to the two classic nuclear ER
isoforms, ERα and ERβ, a G-protein coupled ER (GPR30 or GPER) has been found to be …
their male counterparts. Although estrogen and activation of estrogen receptors (ERs) have
been found to contribute to female protection, the complex mechanisms involved are
unclear. Besides altering gene transcription, estrogen could elicit its cardioprotective effect
via ER-mediated nongenomic signaling pathways. In addition to the two classic nuclear ER
isoforms, ERα and ERβ, a G-protein coupled ER (GPR30 or GPER) has been found to be …
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