Loranthus europaeus was extracted by maceration with 70% ethanol then step wise fractionated with petroleum ether, chloroform, ethyl acetate and the remaining methanol fraction. Ethyl acetate and methanol fractions were analyzed by HPLC for its flavonoids contents & tested for its anti-inflammatory effect by induction paw edema in rats by using fresh egg albumin and measure the paw edema before 30 min. from induction and 30 min, 1 hr, 1.5 hr and 2 hr after induction & compared with piroxicam. Both fractions of loranthus europaeus show non-significant decrease in the mean of increase of paw edema after half hour when compared with negative control, but after one hour of induction ethyle acetate fraction shows significant decrease in the mean of increase in paw edema, while methanol fraction show non-significant decrease in the same parameter when compared with negative control. After one and half hour and two hour of starting measuring, both fraction both fraction show significant decrease in measure parameter when compared with negative control.