The extracts of nine selected Nigerian medicinal plants were investigated on Trypanosoma brucei brucei infected mice. The antiinflammatory properties of hexane fraction of the most promising U. chamae extract was assessed by acute oedema of the mice paw model while the modulatory effect of the extract on Delayed-Type Hypersensitivity (DTH) response on in vivo leucocytes mobilization was evaluated.‘Dose-probing acute toxicity tests’ established an oral and intraperitoneal LD50 for T. ivorensis stem bark as> 1600< 5000 mg/kg and 100 mg/kg respectively, while the oral LD50 of Uvaria. chamae was> 5000 mg/kg. Extracts of Khaya senegalensis, Harungana madagascariensis, Terminalia ivorensis Curcuma