Different kinds of uncertainty, such as variations in manufacturing capability and functionality, as well as changes in demand, make up a dynamically changing environment for many manufacturing systems of today. The ability to adapt to these unforeseen changes, through dynamic decision-making as well as dynamic control capabilities based on the use of real-time manufacturing information and intelligence, is vital to be able to perform at a competitive level while reducing unscheduled downtime. The event-driven Function Block (FB) model of the IEC 61499 standard, as opposed to the time-triggered and data-driven concept of IEC 61331, supports this approach, making it possible to handle, in a responsive and adaptive way, different kinds of uncertainty. Our objective is to develop methodologies for distributed, adaptive and dynamic process planning as well as machine monitoring and control for machining and assembly operations, using event-driven FBs. The implementation and testing of FB-based control for manufacturing equipment has been successfully realized in prototype systems, with control of both CNC machining and robotic assembly operations. The approach of using IEC 61499 FBs for adaptive control in other applications is also investigated, as an adaptive decision support system for operators at manufacturing facilities is under development. We strongly believe that IEC 61499 will play a major role in the shift to adaptive manufacturing systems.