[HTML][HTML] Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3: 6: 3
TK Janganan, VN Bavro, L Zhang… - Journal of Biological …, 2011 - ASBMB
The multiple transferable resistance (mTR) pump from Neisseria gonorrhoeae MtrCDE
multidrug pump is assembled from the inner and outer membrane proteins MtrD and MtrE
and the periplasmic membrane fusion protein MtrC. Previously we established that while
there is a weak interaction of MtrD and MtrE, MtrC binds with relatively high affinity to both
MtrD and MtrE. MtrD conferred antibiotic resistance only when it was expressed with MtrE
and MtrC, suggesting that these proteins form a functional tripartite complex in which MtrC …
multidrug pump is assembled from the inner and outer membrane proteins MtrD and MtrE
and the periplasmic membrane fusion protein MtrC. Previously we established that while
there is a weak interaction of MtrD and MtrE, MtrC binds with relatively high affinity to both
MtrD and MtrE. MtrD conferred antibiotic resistance only when it was expressed with MtrE
and MtrC, suggesting that these proteins form a functional tripartite complex in which MtrC …
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