Evidence that DOCK180 up-regulates signals from the CrkII-p130Cas complex
E Kiyokawa, Y Hashimoto, T Kurata, H Sugimura… - Journal of Biological …, 1998 - ASBMB
DOCK180 is one of the two principal proteins bound to the SH3 domain of the adaptor
protein CrkII. Here, we have studied the involvement of DOCK180 in integrin signaling.
DOCK180 was neither phosphorylated nor bound to CrkII in quiescent NIH 3T3 cells and
3Y1 cells. We found that DOCK180 was phosphorylated and bound to CrkII in NIH 3T3 cells
stimulated with integrin and also in 3Y1 cells transformed by v-src or v-crk. The binding of
DOCK180 to CrkII correlated with the binding of CrkII to p130 Cas, which is a major CrkII …
protein CrkII. Here, we have studied the involvement of DOCK180 in integrin signaling.
DOCK180 was neither phosphorylated nor bound to CrkII in quiescent NIH 3T3 cells and
3Y1 cells. We found that DOCK180 was phosphorylated and bound to CrkII in NIH 3T3 cells
stimulated with integrin and also in 3Y1 cells transformed by v-src or v-crk. The binding of
DOCK180 to CrkII correlated with the binding of CrkII to p130 Cas, which is a major CrkII …
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