Evidence that bacteriophage λ Kil peptide inhibits bacterial cell division by disrupting FtsZ protofilaments and sequestering protein subunits
VM Hernández-Rocamora, C Alfonso… - Journal of Biological …, 2015 - ASBMB
The effects of Kil peptide from bacteriophage λ on the assembly of Escherichia coli FtsZ into
one subunit thick protofilaments were studied using combined biophysical and biochemical
methods. Kil peptide has recently been identified as the factor from bacteriophage λ
responsible for the inhibition of bacterial cell division during lytic cycle, targeting FtsZ
polymerization. Here, we show that this antagonist blocks FtsZ assembly into GTP-
dependent protofilaments, producing a wide distribution of smaller oligomers compared with …
one subunit thick protofilaments were studied using combined biophysical and biochemical
methods. Kil peptide has recently been identified as the factor from bacteriophage λ
responsible for the inhibition of bacterial cell division during lytic cycle, targeting FtsZ
polymerization. Here, we show that this antagonist blocks FtsZ assembly into GTP-
dependent protofilaments, producing a wide distribution of smaller oligomers compared with …
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