This paper presents integrated energy and lighting simulations as a part of wider research focused on the form-finding process of adaptive shading concepts and on the actuation of shading movement using shape memory alloys (SMAs). The use of this new type of microactuator in responsive architectural components presents a challenge because of the limited contraction state of the SMAs. Hence, origami shapes were considered to amplify shading movements thanks to their geometric properties. This study exploited the visual and thermal comfort of a south-oriented office located in Milan, Italy, that was equipped with adaptive origami shading. Two-hundred and ten shapes were considered and the geometry, contraction states, and surface materials were considered as variable properties. The final aim was to explore the potential of adaptive origami shadings in controlling visual and thermal comfort. Daylight illuminance (UDI), daylight glare probability (DGP), and total energy (TE) demand (for cooling, heating, and lighting per year) were used as main metrics for understanding the environmental benefits of the proposed shading devices.