The calcium-activated chloride channel anoctamin1 (ANO1; TMEM16A) is fundamental for
the function of epithelial organs. Mice lacking ANO1 expression exhibit transport defects and
a pathology similar to cystic fibrosis. They also show a general defect of epithelial electrolyte
transport. Here we analyzed expression of all ten members (ANO1–ANO10) in a broad
range of murine tissues and detected predominant expression of ANO1, 6, 7, 8, 9, 10 in
epithelial tissues, while ANO2, 3, 4, 5 are common in neuronal and muscle tissues. When …

Endogenous Ca2+‐activated Cl− currents (CaCCs) are abundant and present in very
different cell types. Very good evidence has been provided that endogenous CaCC is
produced by anoctamin 1 (Ano1) and Ano2. Insight into the physiological role of anoctamins
has been provided for Ano1, Ano2 and Ano6; however, the physiological role of the other
seven members of the anoctamin family remains obscure. Anoctamins 1 and 2 may operate
as individual Ca2+‐sensitive channel proteins or may require accessory subunits for …